Formulation And Characterization Of Telmisartan Using Solid Dispersion Techniques

Telmisartan (TLM) is an angiotensin II receptor antagonist used in the treatment of hypertension. According to BCS (biopharmaceutical classification system) Telmisartan belongs to class II drug, and it is practically insoluble in water and it shows low dissolution profile and poor absorption. The present study is to improve the solubility of Telmisartan by solid dispersion techniques using various methods More than 1500 different CD derivatives have been described in the literature. Generally, CDs can be divided into naturally occurring and chemically modified CDs (18). Another classification is based on their water solubility (Table 2) (19), so one can distinguish hydrophilic, lipophilic and ionizable derivatives. α -CD, β -CD and γ-CD differ from each other depending on the presence of glucose residue. Complexation of molecules to CDs occurs through a non-covalent interaction between themolecule and the CD cavity. This is a dynamic process whereby the guest molecule continuously associates and dissociates from the host CD. CDs are insoluble inmost organic solvents; they are soluble in some polar, aprotic solvents. Although the solubility of CDs is higher in some organic solvents than in water, complexation may not occur readily in non-aqueous solvents because of the increased affinity of the guest for the solvent compared to its affinity for water.